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Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers. Deletion of Pten in a murine model of prostate cancer recapitulates the disease progression seen in humans. Using defined cell lineage markers, we demonstrat...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1345717/ https://ncbi.nlm.nih.gov/pubmed/16432235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510652103 |
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