A short purification process for quantitative isolation of PrP(Sc) from naturally occurring and experimental transmissible spongiform encephalopathies

BACKGROUND: Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases affecting both humans and animals. They are associated with post-translational conversion of the normal cellular prion protein (PrP(C)) into a heat- and protease-resistant abnormal isoform (PrP(Sc)). Detectio...

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Main Authors: Polymenidou, Magdalini, Verghese-Nikolakaki, Susan, Groschup, Martin, Chaplin, Melanie J, Stack, Mick J, Plaitakis, Andreas, Sklaviadis, Theodoros
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2002
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134455/
https://ncbi.nlm.nih.gov/pubmed/12370086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-2-23
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