p21(WAF1 )expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells

BACKGROUND: p21(WAF1), implicated in the cell cycle control of both normal and malignant cells, can be induced by p53-dependent and independent mechanisms. In some cells, MEKs/ERKs regulate p21(WAF1 )transcriptionally, while in others they also affect the post-transcriptional processes. In myogenic...

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Autori principali: Ciccarelli, Carmela, Marampon, Francesco, Scoglio, Arianna, Mauro, Annunziata, Giacinti, Cristina, De Cesaris, Paola, Zani, Bianca M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1343585/
https://ncbi.nlm.nih.gov/pubmed/16351709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-41
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