A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

A cDNA library enriched with Myc-responsive cDNAs but depleted of myc cDNAs was used in a functional screen for growth enhancement in c-myc-null cells. A cDNA clone for mitochondrial serine hydroxymethyltransferase (mSHMT) that was capable of partial complementation of the growth defects of c-myc-nu...

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Bibliographische Detailangaben
Hauptverfasser: Nikiforov, Mikhail A., Chandriani, Sanjay, O'Connell, Brenda, Petrenko, Oleksi, Kotenko, Iulia, Beavis, Andrew, Sedivy, John M., Cole, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133987/
https://ncbi.nlm.nih.gov/pubmed/12138190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.16.5793-5800.2002
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