A Functional Chromatin Domain Does Not Resist X Chromosome Inactivation: Silencing of cLys Correlates with Methylation of a Dual Promoter-Replication Origin

To investigate the molecular mechanism(s) involved in the propagation and maintenance of X chromosome inactivation (XCI), the 21.4-kb chicken lysozyme (cLys) chromatin domain was inserted into the Hprt locus on the mouse X chromosome. The inserted fragment includes flanking matrix attachment regions...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Chong, Suyinn, Kontaraki, Joanna, Bonifer, Constanze, Riggs, Arthur D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12052875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.13.4667-4676.2002
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