A Functional Chromatin Domain Does Not Resist X Chromosome Inactivation: Silencing of cLys Correlates with Methylation of a Dual Promoter-Replication Origin

To investigate the molecular mechanism(s) involved in the propagation and maintenance of X chromosome inactivation (XCI), the 21.4-kb chicken lysozyme (cLys) chromatin domain was inserted into the Hprt locus on the mouse X chromosome. The inserted fragment includes flanking matrix attachment regions...

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Hlavní autoři: Chong, Suyinn, Kontaraki, Joanna, Bonifer, Constanze, Riggs, Arthur D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
DNA Dynamics and Chromosome Structure
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC133922/
https://ncbi.nlm.nih.gov/pubmed/12052875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4667-4676.2002
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