Nucleosome Remodeling by the Human SWI/SNF Complex Requires Transient Global Disruption of Histone-DNA Interactions

We utilized a site-specific cross-linking technique to investigate the mechanism of nucleosome remodeling by hSWI/SNF. We found that a single cross-link between H2B and DNA virtually eliminates the accumulation of stably remodeled species as measured by restriction enzyme accessibility assays. Howev...

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Bibliographic Details
Main Authors: Aoyagi, Sayura, Narlikar, Geeta, Zheng, Chunyang, Sif, Saïd, Kingston, Robert E., Hayes, Jeffrey J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133810/
https://ncbi.nlm.nih.gov/pubmed/11997502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.11.3653-3662.2002
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