Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) induces leukemia in transgenic mice and permanent T-cell growth in vitro. In transformed lymphocytes, it acts as an essential growth factor. Tax stimulates the cell cycle in the G(1) phase by activating the cyclin-dependent kinase (C...

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Detalhes bibliográficos
Main Authors: Haller, Kerstin, Wu, Yalin, Derow, Elisabeth, Schmitt, Iris, Jeang, Kuan-Teh, Grassmann, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133776/
https://ncbi.nlm.nih.gov/pubmed/11971966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3327-3338.2002
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