Construction of an Actinobacillus pleuropneumoniae Serotype 2 Prototype Live Negative-Marker Vaccine

Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol applicatio...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Tonpitak, Walaiporn, Baltes, Nina, Hennig-Pauka, Isabel, Gerlach, Gerald F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Microbial Immunity and Vaccines
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12438394/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.12.7120-7125.2002
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