Construction of an Actinobacillus pleuropneumoniae Serotype 2 Prototype Live Negative-Marker Vaccine

Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol applicatio...

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Библиографические подробности
Главные авторы: Tonpitak, Walaiporn, Baltes, Nina, Hennig-Pauka, Isabel, Gerlach, Gerald F.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2002
Предметы:
Microbial Immunity and Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC133062/
https://ncbi.nlm.nih.gov/pubmed/12438394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.7120-7125.2002
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