Pharmacodynamic Modeling of Clarithromycin against Macrolide-Resistant [PCR-Positive mef(A) or erm(B)] Streptococcus pneumoniae Simulating Clinically Achievable Serum and Epithelial Lining Fluid Free-Drug Concentrations

The association between macrolide resistance mechanisms and clinical outcomes remains understudied. The present study, using an in vitro pharmacodynamic model, assessed clarithromycin (CLR) activity against mef(A)-positive and erm(B)-negative Streptococcus pneumoniae isolates by simulating free-drug...

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Autores principales: Noreddin, Ayman M., Roberts, Danielle, Nichol, Kim, Wierzbowski, Aleksandra, Hoban, Daryl J., Zhanel, George G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC132790/
https://ncbi.nlm.nih.gov/pubmed/12435719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.4029-4034.2002
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