Mechanism by Which Mutations at His274 Alter Sensitivity of Influenza A Virus N1 Neuraminidase to Oseltamivir Carboxylate and Zanamivir

Oseltamivir carboxylate is a potent and specific inhibitor of influenza neuraminidase (NA). An influenza A/H1N1 variant selected in vitro with reduced susceptibility to oseltamivir carboxylate contains a His274Tyr mutation. To understand the mechanism by which a His274Tyr mutation gives rise to drug...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Michael Z., Tai, Chun Y., Mendel, Dirk B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC132783/
https://ncbi.nlm.nih.gov/pubmed/12435681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.3809-3816.2002
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