Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

The guanine modification 7,8-dihydro-8-oxoguanine (8-oxoG) is a potent premutagenic lesion formed spontaneously at high frequencies in the genomes of aerobic organisms. We have characterized a human DNA repair glycosylase for 8-oxoG removal, hOGH1 (human yeast OGG1 homologue), by molecular cloning a...

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Detalhes bibliográficos
Main Authors: Bjorâs, M, Luna, L, Johnsen, B, Hoff, E, Haug, T, Rognes, T, Seeberg, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326315/
https://ncbi.nlm.nih.gov/pubmed/9321410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.20.6314
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