Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice

BACKGROUND: Analysis of an allelic series of point mutations in a gene, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, is a valuable method for discovering the full scope of its biological function. Here we present an efficient gene-driven approach for identifying ENU-induced point mutations...

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Detalhes bibliográficos
Main Authors: Michaud, Edward J, Culiat, Cymbeline T, Klebig, Mitchell L, Barker, Paul E, Cain, KT, Carpenter, Debra J, Easter, Lori L, Foster, Carmen M, Gardner, Alysyn W, Guo, ZY, Houser, Kay J, Hughes, Lori A, Kerley, Marilyn K, Liu, Zhaowei, Olszewski, Robert E, Pinn, Irina, Shaw, Ginger D, Shinpock, Sarah G, Wymore, Ann M, Rinchik, Eugene M, Johnson, Dabney K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1325271/
https://ncbi.nlm.nih.gov/pubmed/16300676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-6-164
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