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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs — adverse effects attributed to suppression of COX-1–derived PGE(2) and prostacyclin (PGI(2)). Evidence from 2 randomized contro...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1323269/ https://ncbi.nlm.nih.gov/pubmed/16395396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27291 |
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