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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs — adverse effects attributed to suppression of COX-1–derived PGE(2) and prostacyclin (PGI(2)). Evidence from 2 randomized contro...

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Detalhes bibliográficos
Main Authors: Grosser, Tilo, Fries, Susanne, FitzGerald, Garret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323269/
https://ncbi.nlm.nih.gov/pubmed/16395396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27291
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