Point Mutations in Herpes Simplex Virus Type 1 oriL, but Not in oriS, Reduce Pathogenesis during Acute Infection of Mice and Impair Reactivation from Latency

In vitro studies of herpes simplex virus type 1 (HSV-1) viruses containing mutations in core sequences of the viral origins of DNA replication, oriL and oriS, that eliminate the ability of these origins to initiate viral-DNA synthesis have demonstrated little or no effect on viral replication in cul...

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Bibliographische Detailangaben
Hauptverfasser: Balliet, John W., Schaffer, Priscilla A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317542/
https://ncbi.nlm.nih.gov/pubmed/16352568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.440-450.2006
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