Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors

MT1-MMP (membrane type 1 matrix metalloproteinase, or MMP-14) is a key enzyme in molecular carcinogenesis, tumour-cell growth, invasion and angiogenesis. Novel and potent MMP inhibitors with a mercaptosulphide zinc-binding functionality have been designed and synthesized, and tested against human MT...

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Detalhes bibliográficos
Main Authors: Hurst, Douglas R., Schwartz, Martin A., Jin, Yonghao, Ghaffari, Mohammad A., Kozarekar, Pallavi, Cao, Jian, Sang, Qing-Xiang Amy
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316292/
https://ncbi.nlm.nih.gov/pubmed/16026329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050545
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