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A computational model of mitochondrial AZT metabolism
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational m...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Portland Press Ltd.
2005
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1316272/ https://ncbi.nlm.nih.gov/pubmed/16060859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050749 |
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