Basic Residues in Hypervariable Region 1 of Hepatitis C Virus Envelope Glycoprotein E2 Contribute to Virus Entry

The N terminus of hepatitis C virus (HCV) envelope glycoprotein E2 contains a hypervariable region (HVR1) which has been proposed to play a role in viral entry. Despite strong amino acid variability, HVR1 is globally basic, with basic residues located at specific sequence positions. Here we show by...

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Autores principales: Callens, Nathalie, Ciczora, Yann, Bartosch, Birke, Vu-Dac, Ngoc, Cosset, François-Loïc, Pawlotsky, Jean-Michel, Penin, François, Dubuisson, Jean
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316016/
https://ncbi.nlm.nih.gov/pubmed/16306604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15331-15341.2005
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