Overexpression of Tumor Necrosis Factor Alpha by a Recombinant Rabies Virus Attenuates Replication in Neurons and Prevents Lethal Infection in Mice

The effect of tumor necrosis factor alpha (TNF-α) on rabies virus (RV) infection of the mouse central nervous system (CNS) was studied, using recombinant RV engineered to express either soluble TNF-α [SPBN-TNF-α(+)] or insoluble membrane-bound TNF-α [SPBN-TNF-α(MEM)]. Growth curves derived from infe...

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Detalhes bibliográficos
Main Authors: Faber, Milosz, Bette, Michael, Preuss, Mirjam A. R., Pulmanausahakul, Rojjanaporn, Rehnelt, Jennifer, Schnell, Matthias J., Dietzschold, Bernhard, Weihe, Eberhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316002/
https://ncbi.nlm.nih.gov/pubmed/16306612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15405-15416.2005
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