Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag

The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in rhesus macaques using an SIVmac239 challenge. Cohorts of either Mamu-A*01(+) or Mamu-A*01(−) macaques were immunized with a DNA...

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Main Authors: Casimiro, Danilo R., Wang, Fubao, Schleif, William A., Liang, Xiaoping, Zhang, Zhi-Qiang, Tobery, Timothy W., Davies, Mary-Ellen, McDermott, Adrian B., O'Connor, David H., Fridman, Arthur, Bagchi, Ansu, Tussey, Lynda G., Bett, Andrew J., Finnefrock, Adam C., Fu, Tong-ming, Tang, Aimin, Wilson, Keith A., Chen, Minchun, Perry, Helen C., Heidecker, Gwendolyn J., Freed, Daniel C., Carella, Anthony, Punt, Kara S., Sykes, Kara J., Huang, Lingyi, Ausensi, Virginia I., Bachinsky, Margaret, Sadasivan-Nair, Usha, Watkins, David I., Emini, Emilio A., Shiver, John W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315991/
https://ncbi.nlm.nih.gov/pubmed/16306625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15547-15555.2005
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