Antichagasic Activity of Komaroviquinone Is Due to Generation of Reactive Oxygen Species Catalyzed by Trypanosoma cruzi Old Yellow Enzyme

A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cyc...

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Main Authors: Uchiyama, Nahoko, Kabututu, Zakayi, Kubata, Bruno K., Kiuchi, Fumiyuki, Ito, Michiho, Nakajima-Shimada, Junko, Aoki, Takashi, Ohkubo, Kei, Fukuzumi, Shunichi, Martin, Samuel K., Honda, Gisho, Urade, Yoshihiro
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
主題:
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315950/
https://ncbi.nlm.nih.gov/pubmed/16304182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.5123-5126.2005
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