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Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells
Origins of replication are expected to recruit initiation proteins like origin recognition complex (ORC) and Cdc6 in eukaryotes and provide a platform for unwinding DNA. Here we test whether localization of initiation proteins onto DNA is sufficient for origin function. Different components of the O...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1315390/ https://ncbi.nlm.nih.gov/pubmed/16322558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1369805 |
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