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A new type of radiosensitive T(–)B(–)NK(+) severe combined immunodeficiency caused by a LIG4 mutation

V(D)J recombination of Ig and TCR loci is a stepwise process during which site-specific DNA double-strand breaks (DSBs) are made by RAG1/RAG2, followed by DSB repair by nonhomologous end joining. Defects in V(D)J recombination result in SCID characterized by absence of mature B and T cells. A subset...

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Detalhes bibliográficos
Main Authors: van der Burg, Mirjam, van Veelen, Lieneke R., Verkaik, Nicole S., Wiegant, Wouter W., Hartwig, Nico G., Barendregt, Barbara H., Brugmans, Linda, Raams, Anja, Jaspers, Nicolaas G.J., Zdzienicka, Malgorzata Z., van Dongen, Jacques J.M., van Gent, Dik C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1312018/
https://ncbi.nlm.nih.gov/pubmed/16357942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26121
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