Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells

A semilinear in-slide model is introduced to remove the intensity effect in the scanning process. It is demonstrated that the intensity effect can be estimated accurately and removed effectively. This normalization step is vital for Affymetrix arrays to reveal relevant biological results when compar...

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Bibliographic Details
Main Authors: Fan, Jianqing, Chen, Yongxiong, Chan, Hiu Man, Tam, Paul K. H., Ren, Yi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1308934/
https://ncbi.nlm.nih.gov/pubmed/16314559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509175102
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