Failure of Commercial Ligase Chain Reaction To Detect Mycobacterium tuberculosis DNA in Sputum Samples from a Patient with Smear-Positive Pulmonary Tuberculosis Due to a Deletion of the Target Region

We report on a strain of Mycobacterium tuberculosis with a deletion in the protein antigen B gene overlapping the probe binding sites for the Abbott Diagnostics LCx M. tuberculosis (LCx-MTB) probe assay. A false-negative result with the LCx-MTB assay delayed a laboratory diagnosis of tuberculosis.

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Détails bibliographiques
Auteurs principaux: Gilpin, Christopher M., Dawson, David J., O'Kane, Gabrielle, Armstrong, John G., Coulter, Christopher
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Case Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC130798/
https://ncbi.nlm.nih.gov/pubmed/12037118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.6.2305-2307.2002
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