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The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway
HMGB1, a non-histone nuclear factor, acts extracellularly as a mediator of delayed endotoxin lethality, which raises the question of how a nuclear protein can reach the extracellular space. We show that activation of monocytes results in the redistribution of HMGB1 from the nucleus to cytoplasmic or...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1307617/ https://ncbi.nlm.nih.gov/pubmed/12231511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf198 |
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