Cryptococcus neoformans Gene Involved in Mammalian Pathogenesis Identified by a Caenorhabditis elegans Progeny-Based Approach

Caenorhabditis elegans can serve as a substitute host for the study of microbial pathogenesis. We found that mutations in genes of the fungal pathogen Cryptococcus neoformans involved in mammalian virulence allow C. elegans to produce greater numbers of progeny than when exposed to wild-type fungus....

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Main Authors: Tang, Robin J., Breger, Julia, Idnurm, Alexander, Gerik, Kimberly J., Lodge, Jennifer K., Heitman, Joseph, Calderwood, Stephen B., Mylonakis, Eleftherios
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Fungal and Parasitic Infections
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307092/
https://ncbi.nlm.nih.gov/pubmed/16299318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.12.8219-8225.2005
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