Cryptococcus neoformans Gene Involved in Mammalian Pathogenesis Identified by a Caenorhabditis elegans Progeny-Based Approach

Caenorhabditis elegans can serve as a substitute host for the study of microbial pathogenesis. We found that mutations in genes of the fungal pathogen Cryptococcus neoformans involved in mammalian virulence allow C. elegans to produce greater numbers of progeny than when exposed to wild-type fungus....

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Autors principals: Tang, Robin J., Breger, Julia, Idnurm, Alexander, Gerik, Kimberly J., Lodge, Jennifer K., Heitman, Joseph, Calderwood, Stephen B., Mylonakis, Eleftherios
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Fungal and Parasitic Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307092/
https://ncbi.nlm.nih.gov/pubmed/16299318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.12.8219-8225.2005
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