Induction of Protective Serum Meningococcal Bactericidal and Diphtheria-Neutralizing Antibodies and Mucosal Immunoglobulin A in Volunteers by Nasal Insufflations of the Neisseria meningitidis Serogroup C Polysaccharide-CRM197 Conjugate Vaccine Mixed with Chitosan

Thirty-six healthy volunteers received either a single intramuscular injection of Neisseria meningitidis serogroup C polysaccharide (MCP)-CRM197 conjugate vaccine in alum or two nasal insufflations 28 days apart of the same vaccine powder, without alum, mixed with chitosan. Nasal immunization was we...

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Detalhes bibliográficos
Main Authors: Huo, Zhiming, Sinha, Ruchi, McNeela, Edel A., Borrow, Ray, Giemza, Rafaela, Cosgrove, Catherine, Heath, Paul T., Mills, Kingston H. G., Rappuoli, Rino, Griffin, George E., Lewis, David J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307064/
https://ncbi.nlm.nih.gov/pubmed/16299322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.12.8256-8265.2005
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