A push–pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L

Although a role for CD4(+) helper cells in CD8(+) cytotoxic T lymphocyte (CTL) induction by vaccines is widely recognized, much less is known about a counterbalancing role of CD4(+) T cells in down-modulating this response, or about ways to optimize vaccine responses through abrogation of this negat...

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Bibliografski detalji
Glavni autori: Ahlers, Jeffrey D., Belyakov, Igor M., Terabe, Masaki, Koka, Rima, Donaldson, Debra D., Thomas, Elaine K., Berzofsky, Jay A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC130579/
https://ncbi.nlm.nih.gov/pubmed/12232042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192251199
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