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Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis

The structural pharmacophore of Taxol, responsible for binding the N terminus of the β-subunit of tubulin to arrest cell proliferation, comprises, in part, the 13-O-(N-benzoyl-3-phenylisoserinoyl) side chain. To identify the side chain transferase of Taxol biosynthesis, a set of transacylases obtain...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Walker, Kevin, Fujisaki, Shingo, Long, Robert, Croteau, Rodney
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130526/
https://ncbi.nlm.nih.gov/pubmed/12232048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192463699
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