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Stabilization of Internal Charges in a Protein: Water Penetration or Conformational Change?
The ionizable amino acid side chains of proteins are usually located at the surface. However, in some proteins an ionizable group is embedded in an apolar internal region. Such buried ionizable groups destabilize the protein and may trigger conformational changes in response to pH variations. Becaus...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Biophysical Society
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1304908/ https://ncbi.nlm.nih.gov/pubmed/15377517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.048454 |
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