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Influence of the Amino Substituents in the Interaction of Ethidium Bromide with DNA

A key step in the rational design of new DNA binding agents is to obtain a complete thermodynamic characterization of small molecule-DNA interactions. Ethidium bromide has served as a classic DNA intercalator for more than four decades. This work focuses on delineating the influence(s) of the 3- and...

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Main Authors: Garbett, Nichola C., Hammond, Nicholas B., Graves, David E.
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304907/
https://ncbi.nlm.nih.gov/pubmed/15465858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.047415
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