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Michaelis-Menten Kinetics under Spatially Constrained Conditions: Application to Mibefradil Pharmacokinetics

Two different approaches were used to study the kinetics of the enzymatic reaction under heterogeneous conditions to interpret the unusual nonlinear pharmacokinetics of mibefradil. Firstly, a detailed model based on the kinetic differential equations is proposed to study the enzymatic reaction under...

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Main Authors: Kosmidis, Kosmas, Karalis, Vangelis, Argyrakis, Panos, Macheras, Panos
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304557/
https://ncbi.nlm.nih.gov/pubmed/15345531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.042143
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