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Loss-of-Function Mutations at the Rim of the Funnel of Mechanosensitive Channel MscL

MscL is a bacterial mechanosensitive channel that is activated directly by membrane stretch. Although the gene has been cloned and the crystal structure of the closed channel has been defined, how membrane tension causes conformational changes in MscL remains largely unknown. To identify the site wh...

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Autori principali: Yoshimura, Kenjiro, Nomura, Takeshi, Sokabe, Masahiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304062/
https://ncbi.nlm.nih.gov/pubmed/15041651
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