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Conformational Changes in Alamethicin Associated with Substitution of Its α-Methylalanines with Leucines: A FTIR Spectroscopic Analysis and Correlation with Channel Kinetics
Alamethicin, a 20 residue-long peptaibol remains a favorite high voltage-dependent channel-forming peptide. However, the structural significance of its abundant noncoded residues (α-methylalanine or Aib) for its ion channel activity remains unknown, although a previous study showed that replacement...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Biophysical Society
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1303787/ https://ncbi.nlm.nih.gov/pubmed/14695266 |
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