Effects of a Carane Derivative Local Anesthetic on a Phospholipid Bilayer Studied by Molecular Dynamics Simulation

Molecular dynamics (MD) simulations of two hydrated palmitoyloleoylphosphatidylcholine (POPC) bilayers each containing eight carane derivative (KP-23) local anesthetic (LA) molecules in neutral (POPC-LA) or protonated (POPC-LAH) forms were carried out to investigate the effect of KP-23 and its proto...

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Bibliographic Details
Main Authors: Pasenkiewicz-Gierula, M., Róg, T., Grochowski, J., Serda, P., Czarnecki, R., Librowski, T., Lochyński, S.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2003
Subjects:
Supramolecular Assemblies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303242/
https://ncbi.nlm.nih.gov/pubmed/12885668
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