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Proline Can Have Opposite Effects on Fast and Slow Protein Folding Phases

Proline isomerization is well known to cause additional slow phases during protein refolding. We address a new question: does the presence of prolines significantly affect the very fast kinetics that lead to the formation of folding intermediates? We examined both the very slow (10–100 min) and very...

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Autors principals: Osváth, Szabolcs, Gruebele, Martin
Format: Artigo
Idioma:Inglês
Publicat: Biophysical Society 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303239/
https://ncbi.nlm.nih.gov/pubmed/12885665
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