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Simulations of Human Lysozyme: Probing the Conformations Triggering Amyloidosis

A natural mutant of human lysozyme, D67H, causes hereditary systemic nonneuropathic amyloidosis, which can be fatal. In this disease, insoluble β-stranded fibrils (amyloids) are found in tissues stemming from the aggregation of partially folded intermediates of the mutant. In this study, we specific...

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Main Authors: Moraitakis, George, Goodfellow, Julia M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Biophysical Society 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302782/
https://ncbi.nlm.nih.gov/pubmed/12668424
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