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Determination of the gelsolin binding site on F-actin: implications for severing and capping.

Gelsolin is a six-domain protein that regulates actin assembly by severing, capping, and nucleating filaments. We have used electron cryomicroscopy and helical reconstruction to identify its binding site on F-actin. To obtain fully decorated filaments under severing conditions, we have studied a der...

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Detalhes bibliográficos
Main Authors: McGough, A, Chiu, W, Way, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302557/
https://ncbi.nlm.nih.gov/pubmed/9533689
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