Increasing protein stability by polar surface residues: domain-wide consequences of interactions within a loop.

We have examined the influence of surface hydrogen bonds on the stability of proteins by studying the effects of mutations of human immunoglobulin light chain variable domain (V(L)). In addition to the variants Y27dD, N28F, and T94H of protein kappa IV Len that were previously described, we characte...

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Detalhes bibliográficos
Main Authors: Pokkuluri, P R, Raffen, R, Dieckman, L, Boogaard, C, Stevens, F J, Schiffer, M
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302478/
https://ncbi.nlm.nih.gov/pubmed/11751325
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