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Measuring pKa of activation and pKi of inactivation for influenza hemagglutinin from kinetics of membrane fusion of virions and of HA expressing cells.

The data for the pH dependence of lipid mixing between influenza virus (A/PR/8/34 strain) and fluorescently labeled liposomes containing gangliosides has been analyzed using a comprehensive mass action kinetic model for hemaglutinin (HA)-mediated fusion. Quantitative results obtained about the archi...

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Bibliographic Details
Main Authors: Mittal, Aditya, Shangguan, Tong, Bentz, Joe
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302350/
https://ncbi.nlm.nih.gov/pubmed/12414698
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