What causes hyperfluorescence: folding intermediates or conformationally flexible native states?

Hyperfluorescent intensity maxima during protein unfolding titrations are often taken as a sign for a thermodynamic folding intermediate. Here we explore another possibility: that hyperfluorescence could be the signature of a "pretransition" conformationally loosened native state. To model...

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Main Authors: Ervin, John, Larios, Edgar, Osváth, Szabolcs, Schulten, Klaus, Gruebele, Martin
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302161/
https://ncbi.nlm.nih.gov/pubmed/12080134
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