Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks.

For a single or a group of Markov channels gating reversibly, distributions of open and closed times should be the sum of positively weighted decaying exponentials. Violation of this microscopic reversibility has been demonstrated previously on a number of occasions at the single channel level, and...

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Autors principals: Wang, Shi-Qiang, Song, Long-Sheng, Xu, Le, Meissner, Gerhard, Lakatta, Edward G, Ríos, Eduardo, Stern, Michael D, Cheng, Heping
Format: Artigo
Idioma:Inglês
Publicat: 2002
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302143/
https://ncbi.nlm.nih.gov/pubmed/12080116
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