Cofilin and DNase I affect the conformation of the small domain of actin.

Cofilin binding induces an allosteric conformational change in subdomain 2 of actin, reducing the distance between probes attached to Gln-41 (subdomain 2) and Cys-374 (subdomain 1) from 34.4 to 31.4 A (pH 6.8) as demonstrated by fluorescence energy transfer spectroscopy. This effect was slightly les...

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Autors principals: Dedova, Irina V, Dedov, Vadim N, Nosworthy, Neil J, Hambly, Brett D, dos Remedios, Cris G
Format: Artigo
Idioma:Inglês
Publicat: 2002
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302102/
https://ncbi.nlm.nih.gov/pubmed/12023237
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