The role of proofreading in signal transduction specificity.

Many intracellular signaling proteins such as MAP kinases and transcription factors require multiple covalent modifications before activating downstream targets. This property suggests that signaling pathways are organized to facilitate proofreading, which expends energy to enhance the specificity o...

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Detaylı Bibliyografya
Asıl Yazarlar: Swain, Peter S, Siggia, Eric D
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2002
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302080/
https://ncbi.nlm.nih.gov/pubmed/12023215
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