Nature of Interaction between basic fibroblast growth factor and the antiangiogenic drug 7,7-(carbonyl-bis[imino-N-methyl-4,2-pyrrolecarbonylimino[N-methyl-4,2-pyrrole]-carbonylimino])-bis-(1,3-naphtalene disulfonate). II. Removal of polar interactions affects protein folding.

Fibroblast growth factor-2 (basic FGF), a potent inducer of angiogenesis, and the naphthalene sulfonic distamycin A derivative, 7,7-(carbonyl-bis[imino-N-methyl-4,2-pyrrolecarbonylimino[N-methyl-4,2-pyrrole]-carbonylimino])-bis-(1,3-naphtalene disulfonate) (PNU145156E), which exhibits in vivo antian...

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Bibliografiske detaljer
Main Authors: Zamai, Moreno, Hariharan, Chithra, Pines, Dina, Safran, Michal, Yayon, Avner, Caiolfa, Valeria R, Cohen-Luria, Rivka, Pines, Ehud, Parola, Abraham H
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302054/
https://ncbi.nlm.nih.gov/pubmed/11964252
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