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Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells

The trans-activation response (TAR) RNA stem–loop that occurs at the 5′ end of HIV RNA transcripts is an important antiviral target and is the site of interaction of the HIV-1 Tat protein together with host cellular factors. Oligonucleotides and their analogues targeted to TAR are potential antivira...

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Autores principales: Turner, John J., Ivanova, Gabriela D., Verbeure, Birgit, Williams, Donna, Arzumanov, Andrey A., Abes, Saïd, Lebleu, Bernard, Gait, Michael J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301599/
https://ncbi.nlm.nih.gov/pubmed/16321967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki991
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