Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels.

We have investigated the action of SNX482, a toxin isolated from the venom of the tarantula Hysterocrates gigas, on voltage-dependent calcium channels expressed in tsa-201 cells. Upon application of 200 nM SNX482, R-type alpha(1E) calcium channels underwent rapid and complete inhibition, which was o...

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Bibliografiske detaljer
Main Authors: Bourinet, E, Stotz, S C, Spaetgens, R L, Dayanithi, G, Lemos, J, Nargeot, J, Zamponi, G W
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301493/
https://ncbi.nlm.nih.gov/pubmed/11423396
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