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Effect of pH on the overstretching transition of double-stranded DNA: evidence of force-induced DNA melting.

When a single molecule of double-stranded DNA is stretched beyond its B-form contour length, the measured force shows a highly cooperative overstretching transition. We have investigated the source of this transition by altering helix stability with solution pH. As solution pH was increased from pH...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Williams, M C, Wenner, J R, Rouzina, I, Bloomfield, V A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2001
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301285/
https://ncbi.nlm.nih.gov/pubmed/11159454
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