Multimerization-cyclization of DNA fragments as a method of conformational analysis.

Ligation of short DNA fragments results in the formation of linear and circular multimers of various lengths. The distribution of products in such a reaction is often used to evaluate fragment bending caused by specific chemical modification, by bound ligands or by the presence of irregular structur...

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Bibliographic Details
Main Authors: Podtelezhnikov, A A, Mao, C, Seeman, N C, Vologodskii, A
Format: Artigo
Language:Inglês
Published: 2000
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301149/
https://ncbi.nlm.nih.gov/pubmed/11053141
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