Mechanical stability of single DNA molecules.

Using a modified atomic force microscope (AFM), individual double-stranded (ds) DNA molecules attached to an AFM tip and a gold surface were overstretched, and the mechanical stability of the DNA double helix was investigated. In lambda-phage DNA the previously reported B-S transition at 65 piconewt...

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Main Authors: Clausen-Schaumann, H, Rief, M, Tolksdorf, C, Gaub, H E
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300792/
https://ncbi.nlm.nih.gov/pubmed/10733978
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